NCEP ATP III เป็นงานวิจัยที่น่าจะเป็นที่ยอมรับมากที่สุดปัจจุบัน
มีข้อแนะนำต่างๆ
และ วิธีการวิจัยอย่างละเอียด มีการคำนวณทางสถิติ
มี N ที่มากที่สุด และน่าจะ กระจายทั่วโลกมากที่สุด
^
"เมื่อคุณเริ่มทำสิ่งที่รักแล้ว วันต่อๆไปก็จะไม่ใช่การทำงาน"..Brian Tracy state exact goal/then analyze what fail the goal/then act/if you don't start/dream still be a dream
หุ้นไม่ใช่แค่เศษกระดาษ มันมีคนทำงานจริง
และการที่บอกว่าทำไม่ไม่กินโดยตรง ผมขอแย้งว่า การกินวิตามินรวม คือการกินอาหารโดยตรง มี การเลือกกินมานับล้านปี แบบลองผิดลองถูกมาแล้ว การกินวิตามินรวม ทางการแพทย์ก็ได้พิสูจน์มาแล้ว ว่าทำงานได้ดีกว่าการกินวิตามินเดี่ยว เช่น กิน A กิน C กิน E ต่อมาบอกว่า กิน A C E รวม น่าจะดีกว่าเป็นต้น
1. Fish Oil กับการเปลี่ยนแปลงของระดับไขมันในเลือด (lipid profile) มีการศึกษาเยอะครับ ผลออกมาคล้ายคลึงกันคือ ลด TG, ไม่ช่วยลด HDL (อย่างมีนัยสำคัญ ไอ้ประเภทลดแค่จิ๊บ ๆ 1% มันไม่พอที่จะบอกว่าลดเพราะ Fish Oil)
ผมเอาตัวอย่าง Abstract มาให้ดู
Diabetologia
Effect of omega 3 fatty acid on plasma lipids, cholesterol and lipoprotein fatty acid content in NIDDM patients.
Goh YK, Jumpsen JA, Ryan EA, Clandinin MT.
Nutrition and Metabolism Research Group, University of Alberta, Edmonton, Canada.
This study was conducted to examine the effect of omega 3 fatty acid supplementation on plasma lipid, cholesterol and lipoprotein fatty acid content of non-insulin-dependent diabetic individuals consuming a higher (0.65, n = 10) or lower (0.44, n = 18 ) ratio of dietary polyunsaturated to saturated fatty acid (P/S). The participants were initially given an olive oil supplement (placebo) equivalent to 35 mg of 18:1. kg body weight-1.day-1 for 3 months. This was followed by two omega 3 supplement periods in a randomized crossover. In these 3-month periods, participants were given a linseed oil supplement equivalent to 35 mg of 18:3 omega 3.kg body weight-1.day-1 or a fish oil supplement equivalent to 35 mg of 20:5 omega 3 + 22:6 omega 3.kg body weight-1. day-1. At the end of each supplement period, a blood sample was drawn from each participant for lipid, lipoprotein, insulin, glucagon and C-peptide analyses. At the end of each 3-month period a 7-day dietary record was completed to calculate dietary fat intake and P/S ratio. Results indicate that fish oil significantly reduced plasma triacylglycerol level (p < 0.05) and increased 20:5 omega 3 and 22:6 omega 3 content of all lipoprotein lipid classes. Linolenic acid supplementation had no effect on plasma triacylglycerol level, but it increased 18:3 omega 3 content of lipoprotein cholesterol ester fractions (p < 0.05). A slight increase in 20:5 omega 3, but not 22:6 omega 3, content was noted in lipoprotein lipid classes as a result of 18:3 omega 3 supplementation. LDL and HDL cholesterol, insulin, glucagon and C-peptide levels were not affected by either omega 3 supplement. It is concluded that a modest intake of omega 3 fatty acids, such as could be obtained from consuming fish regularly, will reduce plasma triglyceride level without affecting LDL or HDL cholesterol levels.
PMID: 9028717 [PubMed - indexed for MEDLINE]
J Nutr
Normal subjects consuming physiological levels of 18:3(n-3) and 20:5(n-3) from flaxseed or fish oils have characteristic differences in plasma lipid and lipoprotein fatty acid levels.
Layne KS, Goh YK, Jumpsen JA, Ryan EA, Chow P, Clandinin MT.
Nutrition and Metabolism Research Group, University of Alberta, Edmonton, Canada.
The study assessed the effect of low doses of fatty acids from fish or flaxseed oil on plasma lipid concentrations in normal humans consuming diets with either high (0.87, n = 11) or low (0.48, n = 15) dietary polyunsaturated/saturated fatty acid (P/S) ratios. The dose of (n-3) fatty acids reflected an (n-3) intake that could easily be attained by selection of foods in a normal diet. The individuals were initially supplemented with olive oil [35 mg 18:1/(kg body weight.d)], and then were randomly assigned to either flaxseed or fish oil [35 mg 18:3(n-3) or 35 mg 20:5(n-3) + 22:6(n-3)/(kg body weight.d), respectively] treatments. Participants consumed each oil supplement for 3 mo. Blood samples were drawn for analysis at the end of each 3-mo period. Plasma triacylglycerol, total, LDL and HDL cholesterol concentrations, and lipoprotein fatty acid concentrations are shown. Fish oil reduced plasma triacylglycerol and increased lipoprotein levels of 20:5(n-3) and 22:6(n-3). The flaxseed oil did not alter plasma triacylglycerol level and produced small changes in 20:5(n-3) and 22:6(n-3) concentrations. Total, LDL and HDL cholesterol levels were not affected by either (n-3) fatty acid. Significant differences in plasma triacylglycerol concentrations and total and LDL cholesterol levels were found between the two dietary P/S groups after all oil treatment periods. Levels of 18:3(n-3), 20:4(n-6), 20:5(n-3), and 22:6(n-3) in LDL were also different in high vs. low dietary P/S groups for all oil treatments and in the VLDL for the olive oil and fish oil supplementation. This study indicates that low intake of purified fish oil induces changes in plasma triacylglycerol, 20:5(n-3) levels in VLDL, LDL, and HDL, and 22:6(n-3) levels in LDL and HDL that are apparent after 3 mo and which might influence atherogenicity of lipoprotein particles in normal free-living individuals.